Glycyrrhizin Alleviates Nonalcoholic Steatohepatitis via Modulating Bile Acids and Meta-Inflammation
نویسندگان
چکیده
منابع مشابه
Nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is being increasingly recognized as a common liver disorder that represents the hepatic manifestation of the metabolic syndrome, a variably defined aggregate of disorders related to obesity, insulin resistance, type II diabetes, hypertension and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is the progressive form of liver injury that carries a ris...
متن کاملNonalcoholic steatohepatitis and diabetes.
a Unidad de Hepatología, Hospital Clinic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, España b Unitat de Suport a la Recerca (USR) Metropolitana Nord, Institut d’Investigació en Atenció Primaria (IDIAP) Jordi Gol, Centro de Investigación en Red de Enfermedades Hepáticas y Digesti...
متن کاملNonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized form of chronic liver disease affecting both children and adults that has gained increased recognition. Recently NAFLD has been associated with insulin resistance and its incidence and prevalence is likely increasing, paralleling the rise in obesity and diabetes mellitus in the United States. The article includes current thoughts on ...
متن کاملRecombinant SFRP5 protein significantly alleviated intrahepatic inflammation of nonalcoholic steatohepatitis
BACKGROUND Secreted frizzled-related protein 5 (SFRP5) is an anti-inflammatory adipokine modulating metabolism dysfunction. This study aims to observe the effect of recombinant SFRP5 protein on nonalcoholic steatohepatitis (NASH). METHODS We set up a prokaryotic expression system and purified the recombinant SFRP5 protein. Recombinant SFRP5 protein was further identified by SDS-PAGE, western ...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2018
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.118.082008